PanTum® Detect is a multi-tumor screening blood test that measures levels of two enzyme biomarkers present within your immune cells (macrophages). If the enzyme biomarkers levels are raised the test is positive.

PanTum® Detect test detects the presence of two enzyme biomarkers in whole human blood, which are increasingly formed in all solid tumors – even in the early, asymptomatic phase. The two enzyme biomarkers are called Transketolase-like-1 (TKTL1) and DNaseX (Apo10).

TKTL1 provides an indication of switch towards invasive growth. TKTL1 regulates anaerobic glucose metabolism (Warburg effect) which is fermentation of glucose using the Pentose Phosphate Pathway resulting in the formation of lactic acid and breakdown of collagen matrix leading to metastasis.

DNaseX (Apo10) provides indication of tumor proliferation. Elevated levels of DNaseX (Apo10) enzyme is the result of disruption of programmed cell death (Apoptosis).

No, the test does not show the type, spread or location of the cancer. PanTum® Detect is a screening blood test and a positive result indicates the presence of a tumor if the levels of two enzyme biomarkers are raised. In case of a positive test result, Imaging (PET/CT, MRI) & Pathology diagnostics (Tumor markers, Histopathology / Cytology) are carried out for further confirmatory diagnosis.

The “Cancer-Scan” program combines blood testing with PanTum® Detect and confirmatory techniques (Imaging + Pathology) for those who test positive as an integrated multi-tumor screening concept for early detection of cancer.

Individuals who want to undergo PanTum® Detect need to be in a healthy state to ensure highest blood sample quality.

Following are the inclusion / exclusion criteria for undergoing PanTum Detect blood test.

• Individuals less than 18 years of age.
• Individuals diagnosed with cancer and on active treatment.
• Individuals who have undergone imaging investigation where contrast media has been used (MRI / PET-CT / CT) can undergo this blood test after 1 week.
• Individuals who have suffered from acute bacterial or viral infection (Covid, Acute herpes zoster, Typhoid, Viral hepatitis, etc.) can undergo this blood test after 2 weeks of recovery.
• Individuals who have been administered any vaccination can undergo this blood test after 4 weeks.
• Individuals who are on following medications can undergo this blood test after stopping the medication for 8 weeks.
  • Corticosteroid containing drugs
  • Immunosuppressants (Methotrexate, Cyclosporine, Azathioprine, Tacrolimus, Mycophenolate, Rapamycin, Sirolimus, Adalimumab, Infliximab etc.)
  • Amygdalin (Vitamin B17)
  • GMCSF (Sargramostim)
• Individuals who have suffered from febrile illness or any major surgery or any severe trauma can undergo this blood test after 8 weeks of recovery.
• Individuals in remission (free of cancer and not on any active treatment) for 1 year can undergo this test.