PanTum® Detect test detects the presence of two enzyme biomarkers in whole human blood, which are increasingly formed in all solid tumors – even in the early, asymptomatic phase. The two enzyme biomarkers are called Transketolase-like-1 (TKTL1) and DNaseX (Apo10).
TKTL1 provides an indication of switch towards invasive growth. TKTL1 regulates anaerobic glucose metabolism (Warburg effect) which is fermentation of glucose using the Pentose Phosphate Pathway resulting in the formation of lactic acid and breakdown of collagen matrix leading to metastasis.
DNaseX (Apo10) provides indication of tumor proliferation. Elevated levels of DNaseX (Apo10) enzyme is the result of disruption of programmed cell death (Apoptosis).